In 1887, the powerful vampire Lilith is vanquished by a vampire council and four amulets avoid her return to the world of living. In the present days, the greedy Realtor Russel Bayne is pressing Alex Layton to sell her store of esoteric products to him. While driving back home, Russel stops his Ferrari to help a young woman that has troubles with her Volkswagen Beetle in a lonely road. However, they are attacked by a werewolf and Russel transforms into one a couple of nights later. Meanwhile, a vampire clan led by the evil Von Griem is retrieving the ancient amulets to bring Lilith back. When Von Griem's minions try to abduct Russel, Alex helps him and Russel teams up with Jacob Van Helsing and his peer group to avoid the return of the devilish Lilith.

Ex-Navy Seal Bobby Kalinowski lives a quiet, peaceful life as a landscape architect in an LA suburb with his wife Dawn and 16 year old daughter Brianna. Tonight they are invited out for an evening on the town by new neighbors clay and Elise Freeman to a happening club downtown. Little did they know that this would be the start of a life or death ordeal for the group. While at the club, Dawn is accosted by one of the club owners, Ethan Bordas. When Bobby intervenes and accidentally kills Ethan defending his wife, his enraged older brother, Seth, puts a one hundred thousand dollar bounty on his head. Now Bobby must escape LA while being pursued by every criminal, wise guy and thug in the city. Bobby decides to separate from his wife and neighbors and revert to his Navy Seal training to survive. To complicate matters, Seth has a corrupt police sergeant preventing Bobby from getting any help from the law...